Taking more exercise and eating the right
foods may help increase levels of an enzyme vital for guarding
against age-related cell damage, work suggests.
Among 24 men asked to adopt healthy lifestyle changes for
a US study in The Lancet Oncology, levels of telomerase increased
by 29% on average.
Telomerase repairs and lengthens telomeres, which cap and
protect the ends of chromosomes housing DNA.
As people age, telomeres shorten and cells become more susceptible
to dying.
It is the damage and death of cells that causes aging and
disease in people.
Several factors such as smoking, obesity and a sedentary
lifestyle are associated with shorter-than-average telomeres.
Professor Dean Ornish, from the Preventive Medicine Research
Institute in California, and his team wanted to find out if
improvements in diet and lifestyle might have the opposite
effect.
They asked 30 men, all with low-risk prostate cancers, to
take part in a three-month trial of comprehensive lifestyle
changes.
These consisted of a diet high in fruit and vegetables, supplements
of vitamins and fish oils, an exercise regimen and classes
in stress management, relaxation techniques and breathing
exercises.
Telomerase activity was measured at the beginning of the
trial and again at the end.
Among the 24 men who had sufficient data for analysis, blood
levels of telomerase increased by 29% on average.
Increases in telomerase activity were linked with decreases
in "bad" LDL cholesterol and decreases in one measure of stress
- intrusive thoughts.
The researchers say it is too early to tell if the boost
in telomerase levels will translate to a change in telomere
length.
But there is evidence to suggest that telomere shortness
and low telomerase activity might be important risk factors
for cancer and cardiovascular disease.
"This might be a powerful motivator for many people to beneficially
change their diet and lifestyle," they told The Lancet Oncology.
Professor Tim Spector, from King's College London, who has
been researching aging and telomeres, said: "This work builds
on what we already know.
"Lifestyle can affect your telomeres. It would be interesting
to find out whether it is diet, stress or both that is important."