Why Do Diets Rich In Fruits
And Vegetables Fight Cancer?
A complex carbohydrate called pectin
may help explain why diets rich in fruits and vegetables can
lower cancer risk, according to scientists.
In lab experiments, UK researchers found that particular components
of pectin bind to, and possibly inhibit, a protein believed
to facilitate the spread of cancer throughout the body.
The findings, published in the FASEB Journal, offer up one
more reason to get your fruits and vegetables, according to
the investigators. They also support past research suggesting
that modified forms of pectin could help battle cancer, the
investigators say.
Previous research has shown that modified pectin can kill or
prevent the spread of tumor cells in the test tube, explained
Patrick Gunning, the lead researcher on the new study. These
latest findings point to the mechanism by which pectin may offer
cancer protection.
Gunning and his colleagues at the Institute of Food Research
in Norwich found that certain sugars in pectin bind to galectin-3,
a protein on the surface of tumor cells that helps the cells
grow and spread throughout the body.
This binding, in turn, may allow pectin to inhibit galectin-3,
and thereby slow or even reverse the spread of cancer cells,
Gunning explained.
There are still many questions, however, he said -- one being
how the body takes up the particular "bioactive fragments" within
pectin.
Pectin is often used as a gelling agent in jams and jellies,
but Gunning advised against loading up on the condiments. Research
has not shown processed fruit products to be greater cancer
fighters than fresh fruit -- and, Gunning pointed out, jams
and jellies are typically high in added sugar.
"At present," he said, "given what we know from our study and
the others, we feel that the best advice is to eat plenty of
fruit and vegetables in the likelihood that it will supply bioactive
fragments from the pectins."