Comprehensive Study: Approved Genetically
Modified Foods Linked To Organ Damage
In what is being described as the first ever and most comprehensive
study of the effects of genetically modified foods on mammalian
health, researchers have linked organ damage with consumption
of Monsantos GM maize.
Three varieties of Monsantos GM corn, Mon 810, Mon 863
and NK 603, were approved for consumption by US, European and
several other national food safety authorities. Made public by
a European court in 2005, Monsantos confidential raw data
of its 2002 feeding trials on rats that these researchers analyzed
is the same data, ironically, that was used to gain that approval.
The Committee of Research and Information on Genetic Engineering
(CRIIGEN) and Universities of Caen and Rouen studied Monsantos
90-day feeding trials data of insecticide producing Mon 810, Mon
863 and Roundup® herbicide absorbing NK 603 varieties of GM
The data clearly underlines adverse impacts on kidneys
and liver, the dietary detoxifying organs, as well as different
levels of damages to heart, adrenal glands, spleen and haematopoietic
system, reported Gilles-Eric Séralini, a molecular
biologist at the University of Caen.
Although different levels of adverse impact on vital organs were
noticed between the three GMOs, the 2009 research shows specific
effects associated with consumption of each, differentiated by
sex and dose.
Their December 2009 study
appears in the International Journal of Biological Sciences (IJBS).
This latest study conforms with a 2007
analysis by CRIIGEN on Mon 863, published in Environmental
Contamination and Toxicology, using the same data.
the 2007 conclusions, stating:
The analyses conducted by these authors are not consistent
with what has been traditionally accepted for use by regulatory
toxicologists for analysis of rat toxicology data.
[Also see Doull J, Gaylor D, Greim HA, et al. Report
of an expert panel on the reanalysis by Séralini et al.
(2007) of a 90-day study conducted by Monsanto in support of
the safety of a genetically modified corn variety (MON 863).
Food Chem Toxicol. 2007; 45:2073-2085.]
Séralini explained that their study goes beyond Monsantos
analysis by exploring the sex-differentiated health effects on
mammals, which Doull, et al. ignored:
Our study contradicts Monsanto conclusions because Monsanto
systematically neglects significant health effects in mammals
that are different in males and females eating GMOs, or not
proportional to the dose. This is a very serious mistake, dramatic
for public health. This is the major conclusion revealed by
our work, the only careful reanalysis of Monsanto crude statistical
data. [Communication to author]
Other problems with Monsantos conclusions
When testing for drug or pesticide safety, the standard protocol
uses three mammalian species. The subject studies only used rats,
yet won GMO approval in more than a dozen nations.
Chronic problems are rarely discovered in 90 days; most often
such tests run for up to two years. Tests lasting longer
than three months give more chances to reveal metabolic, nervous,
immune, hormonal or cancer diseases, wrote Seralini, et
al. in their Doull rebuttal. [See How Subchronic and Chronic
Health Effects can be Neglected for GMOs, Pesticides or Chemicals.
IJBS; 2009; 5(5):438-443.]
Further, Monsantos analysis compared unrelated feeding
groups, muddying the results. The June 2009 rebuttal explains,
In order to isolate the effect of the GM transformation
process from other variables, it is only valid to compare the
with its isogenic
The researchers conclude that the raw data from all three GMO
studies reveal novel pesticide residues will be present in food
and feed and may pose grave health risks to those consuming them.
They have called for an immediate ban on the import and
cultivation of these GMOs and strongly recommend additional long-term
(up to two years) and multi-generational animal feeding studies
on at least three species to provide true scientifically valid
data on the acute and chronic toxic effects of GM crops, feed
Human health, of course, is of primary import to us, but ecological
effects are also in play. Ninety-nine percent of GMO crops either
tolerate or produce insecticide. This may be the reason we see
colony collapse disorder and massive
butterfly deaths. If GMOs are wiping out Earths pollinators,
they are far more disastrous than the threat they pose to humans
and other mammals.
January 7, 2010