Recent research has discovered 34 new beneficial compounds in pure maple syrup and confirmed that 20 compounds discovered last year in preliminary research play a key role in human health. New research conducted at the University of Tokyo suggests that pure maple syrup may promote a healthy liver.
On March 30 at the 241st American Chemical Society's National Meeting in Anaheim, Calif. the URI assistant pharmacy professor is telling scientists from around the world that his URI team has now isolated and identified 54 beneficial compounds in pure maple syrup from Quebec, five of which have never been seen in nature.
"I continue to say that nature is the best chemist, and that maple syrup is becoming a champion food when it comes to the number and variety of beneficial compounds found in it," Seeram said. "It's important to note that in our laboratory research we found that several of these compounds possess anti-oxidant and anti-inflammatory properties, which have been shown to fight cancer, diabetes and bacterial illnesses."
Now, a pilot study, conducted by Dr. Keiko Abe of the University of Tokyo’s Graduate School of Agricultural and Life Sciences, showed that healthy laboratory rats fed a diet in which some of the carbohydrate was replaced with pure maple syrup from Canada yielded significantly better results in liver function tests than the control groups fed a diet with a syrup mix containing a similar sugar content as maple syrup. The results will be published in the November, 2011 issue of Bioscience, Biotechnology, and Biochemistry.
Although most healthy individuals take liver function for granted, liver health is of great importance because of the hundreds of vital functions it performs that are essential to human life, which include storing energy (glycogen) and regulating blood glucose, the production of certain amino acids (building blocks of protein), filtering harmful substances from the blood. Liver disease not related to alcohol consumption is estimated to affect 25% of people in the United States, according to the American Liver Foundation. It shows up most often in middle aged people who are overweight, have abnormal blood lipids and diabetes or insulin resistance conditions when grouped together, are known as metabolic syndrome.
“It is important to understand the factors leading to impaired liver function – our lifestyle choices including poor diet, stress and lack of exercise, as well as exposure to environmental pollutants that produce tissue-damaging free radicals,” says Dr. Melissa Palmer, clinical professor and medical director of hepatology at New York University Plainview. “The preliminary results of this research are encouraging and emphasize the importance of choosing a healthy diet to help counteract the lifestyle and environmental factors that may impact liver function, even our choice of a sweetener. In addition to Dr. Abe’s recent findings, published research suggests that pure maple syrup may prove to be a better choice of sweetener because it was found to be rich in polyphenolic antioxidants and contains vitamins and minerals,” notes Palmer.
Click here to view a brief video detailing the liver health findings with Dr. Keiko Abe and Dr. Melissa Palmer.
The animals were evaluated using the latest analytical methods including gene expression profiling called nutrigenomics. In the study, rats were fed diets consisting of 20% pure maple syrup, or 20% syrup mixture with similar sugar content as maple syrup. After 11 days, the rats on the maple syrup diet showed significantly decreased levels of liver enzymes AST, ALT and LDH in the blood, standard biomarkers for evaluating liver function. The gene expression profiling observations also suggest a mechanism whereby the maple syrup diet caused genes involved in the production of harmful ammonia in the liver to down-regulate, that is, to be less active.
“This research contributes to our growing understanding of the incredible health potential of maple syrup,” remarked Serge Beaulieu, President of the Federation of Quebec Maple Syrup Producers. “We learned previously that maple syrup contains antioxidant compounds that may actually help regulate glucose metabolism and increase insulin release, possibly aiding in the management of type 2 diabetes. And now Dr. Abe is exploring the relationship between maple syrup consumption and liver health. Her current findings give us even more reason to enjoy our maple syrup.”