A new UCSF analysis of tobacco industry documents shows that Philip Morris USA manipulated data on the effects of additives in cigarettes, including menthol, obscuring actual toxicity levels and increasing the risk of heart, cancer and other diseases for smokers.
Manufacturers from both Big Tobacco and Big Pharma deny the presence of any danger in their products and even spend millions of dollars trying to discredit the research that points to problems.
Tobacco industry information can’t be taken at face value, the researchers conclude. They say their work provides evidence that hundreds of additives, including menthol, should be eliminated from cigarettes on public health grounds.
The article is published in PLoS Medicine.
In the new, independent study, the scientists reassessed data from Philip Morris’ “Project MIX,” which detailed chemical analyses of smoke and animal toxicology studies of 333 cigarette additives. Philip Morris, the nation’s largest tobacco company, published its findings in 2002.
By investigating the origins and design of Project MIX, the UCSF researchers conducted their own inquiry into the Philip Morris results. They stressed that many of the toxins in cigarette smoke substantially increased after additives were added to cigarettes.
They also found, after obtaining evidence that additives increased toxicity, that tobacco scientists adjusted the protocol for presenting their results in a way that obscured these increases.
“We discovered these post-hoc changes in analytical protocols after the industry scientists found that the additives increased cigarette toxicity by increasing the number of fine particles in the cigarette smoke that cause heart and other diseases,” said senior author Stanton A. Glantz, PhD, UCSF professor of medicine and director of the Center for Tobacco Control Research and Education at UCSF.
“When we conducted our own analysis by studying additives per cigarette -- following Philip Morris’ original protocol -- we found that 15 carcinogenic chemicals increased by 20 percent or more,” he said.
Similarities To Big Pharma
Tobacco companies and pharmaceutical companies share so many commonalities and industry practices, that it is quite difficult to deny their ideological similarities.
Keep harmful findings of their products from the public
2. Create fraudulent tests and arrange clinical trials by paying researchers to produce desired results.
3. Target Hollywood and children.
4. Have ties to organized crime.
Are permitted by government to continue to sell harmful products simply by publishing warning data.
Vaccines contain known toxic ingredients and excipients including carcinogens, immunotoxins, neurotoxins and sterility agents such as formaldehyde, neomycin, octoxynol-10, MSG and polysorbate 80. All are known to be hazardous to human health yet pubic health agencies and international health bodies such as the WHO continue to promote their injection into very young children.
The failure for both Big Tobacco and Big Pharma to discover the many toxic effects are always the same. Their animal studies are too small and too short.
There are statistically important changes
to detect including biological effects in larger studies especially in the long-term.
Pharmacokinetic properties are also rarely if ever addressed in vaccine
studies since the process would involved using human guinea pigs. Yet, pharmacokinetic studies are the only way researchers can properly assess bodily absorption, distribution, metabolism and excretion of any vaccine ingredients.
Vaccine and drug studies are routinely conducted by scientists with ties to pharmaceutical companies. Similarly, the results of “Project MIX” were first published as four papers in a 2002 edition of Food and Chemical Toxicology, a journal whose editor and many members of its editorial board had financial ties to the tobacco industry. While Philip Morris was trying to get the papers published, the company scientist who led Project Mix sent an email to a colleague¬† describing the peer review process as an inside job.
In the new study, the researchers used documents made public as a result of litigation against the tobacco industry. The documents are available to the public through UCSF’s Legacy Tobacco Documents Library.