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JUNE 19, 2015 by MAE CHAN
The Future Of Understanding Human Immunity Will Rest On Our Knowledge of Bacteria and Inflammation

Throughout the world, we will see proliferating technologies that will eventually assist in a greater understanding of the mechanisms that regulate the incredible interactions between nutrition and immunity. The short-sighted conventional medical approach of inserting microorganisms into the body will be replaced by our understanding of new aspects in the complex relationships between bacteria and inflammatory processes which ultimately cause disease more than any single factor within the human body.

Conventional medicine has learned one thing very well in the last 200 years. That is to use chemicals to depress our immune system; including foreign DNA/RNA from animal tissues to depress immunity. The medical thought is that we trade a small immune depression for an immunity to one disease. Essentially, we are trading a total immune system depression (our only defense against all known disease - including millions of pathogens) for a temporary immunity against one disease. We are trading mumps and measles for cancer and other deadly diseases.

The relationship between nutrition and immunity is changing, and it's changing fast. Professor Philip Calder from the University of Southampton, UK, said that new '-omics' technologies that can mine information from large sets of data, in combination with recent advances in cellular and molecular biology has resulted in huge steps forward in the understanding of how nutrition and diet can play a role in supporting immunity -- and this is just the beginning.

Calder believes such advances are resulting in a shift from 'classical' ideas of immuno-nutrition towards a greater understanding of the intricate relationship between the human immune system and our diet.

"The old idea of immune-nutrition was that you give people specific nutrients and then you improve some sort of immune functioning," explained Calder.

However, the nutrition and immunity expert believes that industry and academia need to move away from such 'classical markers' of immunity and archaic ideas of 'boosting' the immune system.

"This is an area which is tremendously exciting, but is also moving forward very quickly," he said.

"We are moving away from the idea of just looking to protecting against infectious disease and moving towards implications for chronic diseases of aging."

Two Way Interaction

"I think, probably the really key area which is taking off is the fact that the immune system is very much influenced by bacteria -- particularly in the gut, but also in the skin and elsewhere," said Calder.

"There is this sort of two way interaction between the immune system and these bacteria," he explained.

The 1.5 kilograms of bacteria that we each carry in our intestines have an enormous impact on our health and well being. The bacteria normally live in a sensitive equilibrium but if this equilibrium is disrupted our health could suffer.

As has always been known, this two-way street involves the immune system sensing bacteria that are present -- whether they are pathogens or more 'friendly' bacteria.

Scientists working on the EU research project MetaHIT have uncovered more than 3.3 million genes from gut bacteria found in people from Spain and Denmark. These genes could play a key role in understanding and treating a range of serious illnesses. According to Professor Karsten Kristiansen from the University of Copenhagen's Department of Biology, recent discoveries in diabetes research are important steps in the comprehensive international research that is currently underway to investigate the interplay between intestinal bacteria and health.

By maintaining a balance between beneficial and harmful bacteria, good bacteria help to manage acute infections. They restore the balance of good bacteria, thus helping to normalize digestive function and boost immunity.

"Coming from it the other way, there seems to be a very important role for specific bacteria in terms of shaping the immune response," said Calder -- adding that bacterial colonies and the immune system co-exist in a way that is mutually beneficial in a healthy person.

Probiotics offset other intestinal bacteria that produce putrefactive and carcinogenic toxins. If harmful bacteria dominate the intestines, essential vitamins and enzymes are not produced and the level of harmful substances rises leading to cancer, liver and kidney disease, hypertension, arteriosclerosis and abnormal immunity. Harmful bacteria can proliferate under many different circumstances including peristalsis disorders, surgical operations of the stomach or small intestine, liver or kidney diseases, pernicious anaemia, cancer, radiation or antibiotic therapies, chemotherapy, immune disorders, emotional stress, poor diets and aging.

One key aspect of this two way relationship is the regulation of the immune system against dysfunctions, which Calder noted can be 'very important' in the development of many diseases. These include classic inflammatory diseases but also -- and perhaps more importantly, said Calder -- metabolic diseases such as cardiovascular disease, fatty liver disease, and even obesity.

"It seems that there is a link between bacterial exposures [to food and nutrients], the immune response that occurs, and even these metabolic diseases."

It's common knowledge that a mother's milk can help beef up a baby's immune system. New research indicates that the protective effects of gut bacteria can be transferred from mother to baby during breastfeeding. Work published in Environmental Microbiology shows that important gut bacteria travels from mother to child through breast milk to colonize a child's own gut, helping his or her immune system to mature.

Scientific evidence is mounting that the trillions of microbes that call the human body home can influence our gut-linked health, but more recently, researchers are discovering that gut microbes also may affect neurology--possibly impacting a person’s cognition, emotions and mental health.

New Links

Calder said these new links have given the industry various challenges to opportunities to tackle: "One of them is that you need new technologies to understand the nature of these interactions, but you also need to understand the mechanisms behind those interactions."

"You have sophisticated -omics technologies which allow identification of large numbers of things you are analysing -- be they gene sequences, RNA's, protein, or metabolites," said Calder. "That capability to measure this large number of things, in a reasonable time and at a reasonable cost is certainly very important."

"Plus, it's also useful to identify the mechanisms, and for this you really need advances to be coming from cellular and molecular biology."
However, the expert added that all of these interactions are still is focused on the host: "Of course the other side of that is to find out about the bacteria -- and that relies on these same technologies."

These technologies have also brought about huge advances in the identification of types of bacteria present in the human gut system, in addition to those present in the oral cavity and on the skin.

Calder believes that so far, large scale, but ultimately individual projects have done well to push boundries in knowledge with projects such as those to sequence the microbial genome.

"But in the meantime somebody else is also finding out new information about the host," he reiterates. "Clearly there is a need to put all of these together."

"I think those integrations will happen over the next few years, as people realise this information needs to be brought together to make sense of it

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