U.S. scientists are getting a better understanding of human
tears.
A team from Ohio State University
say they've identified a new class of lipids (a type of fat)
that makes up part of the tear film.
These new lipids, including a specific kind called oleamide,
are contained in a layer of tear film called meibum, which
is the outermost of the three distinct layers in tear film.
There is also a middle, watery layer and an inner layer of
mucus.
The meibum, which includes fatty, oily substances, is spread
over the surface of the eyes each time we blink. The meibum
keeps the watery middle layer in place, ensuring the eyes
stay moist.
Identifying the lipids contained in the meibum may help researchers
learn more about the causes of eye problems such as dry eye
disease, which affects about 12 million to 14 million Americans,
said study author Kelly Nichols, an assistant professor of
optometry at Ohio State.
"The lack of certain compounds in the tear film may result
in a number of different eye-related disorders, including
dry eye. The amount of oleamide and related lipids in tear
film may be related to these disorders," Nichols said in a
prepared statement.
The study is published in the current issue of Investigative
Ophthalmology and Visual Science.
It was already known that oleamide plays a role in the brain,
where one of its tasks is to help induce sleep, and in the
central nervous system. This is the first study to identify
oleamide and related lipids in tear film.
"The findings could give us more insight into the role of
lipid activity in humans and may also indicate a new function
for oleamide and related lipids in cellular signaling in the
eye and in the maintenance of tear film," Nichols said.
The function of oleamide and related lipids in tear film
isn't fully understood.
"Oleamide appears to predominate in tear film. It's there
for a reason, but we're not sure yet what that reason is,"
Nichols said.