It may be possible to add a compound to high-fat
food that can cut the risk of an unhealthy diet leading to
diabetes, say scientists.
US Department of Agriculture chemists found
the compound, a form of soluble cellulose, slowed down the
rate of fat absorption.
Animal tests showed this cut the risk of
insulin resistance - a condition which often leads to type
2 diabetes.
Details were presented to a meeting of the
American Chemical Society.
The compound, HPMC, is already used as an additive in many foods
and drugs - mostly to provide texture.
But the US team believe theirs is the first
study to show that it might also have potential as a so-called
functional food ingredient, helping to boost health.
While they are hopeful that the compound
could prove useful at reducing the risk of diabetes, they
say it is unlikely to prevent obesity too.
Researcher Dr Wallace Yokoyama said: "Obviously,
the less fat you eat, the better off you are.
"But if you're going to eat high-fat foods,
then adding HPMC to it might help limit the damage."
Hamster diet
The researchers fed hamsters a diet containing
fat levels comparable to a typical American fast food diet
for four weeks.
They found that the animals developed insulin
resistance.
However, another group of hamsters fed a
similar high-fat diet but with HPMC substituted for the insoluble
fibre normally found in high fat food showed no signs of developing
insulin resistance.
The researchers believe HPMC slows down the
absorption of fats, preventing high fat levels from overwhelming
the digestive system.
It also seems to control the way in which
fat is transported to the body's adipose tissue, where it
is normally stored.
Fats that are taken into the body too quickly
- for instance during a fast food binge - tend to be rapidly
shunted to non-adipose tissues such as the liver, heart and
pancreas, where they can do extensive damage to cells.
Pancreatic damage can lead to diabetes.
The researchers estimate that only around
five grams of HPMC would be needed to have a positive impact
on health.
However, they say that further work is needed
to pin down the exact effect.
Amanda Vezey, of the charity Diabetes UK,
said: "Although this research is interesting it has only been
tested so far on animals and much more work would need to
be done before we could draw any conclusions about its effect
on humans.
"Even if this were to be successful, it would
not reduce all the other risks created by eating a high-fat
diet and being overweight."
Ms Vezey said there was already evidence
which proves that in some cases diabetes can be prevented
or delayed by maintaining a healthy weight, eating a balanced
diet and doing regular physical activity.
"Although they do take some effort, making
these lifestyle changes are definitely the best way of reducing
your risk of developing Type 2 diabetes."