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Chiropractic Influence on
Oxidative Stress and DNA Repair
There is a growing body of evidence that wellness care
provided by doctors of chiropractic may reduce health care
costs, improve health behaviors, and enhance patient perceived
quality of life. Until recently, however, little was known
about how chiropractic adjustments affected the chemistry
of biological processes on a cellular level.
In a landmark study published this week in the Journal of
Vertebral Subluxation Research (JVSR; http://www.jvsr.com), chiropractors collaborating with researchers
at the University of Lund found that chiropractic care could
influence basic physiological processes affecting oxidative
stress and DNA repair. These findings offer a scientific
explanation for the positive health benefits reported by
patients receiving chiropractic care.
The researchers measured serum thiol levels in 21 patients
under short-term chiropractic care and 25 patients under
long-term chiropractic care. The results were compared to
those of a non-chiropractic treated control group of 30
subjects. Long-term chiropractic care of two or more years
was shown to re-establish a normal physiological state independent
of age, sex, or nutritional supplements. Symptom-free or
primary wellness subjects under chiropractic care demonstrated
higher mean serum thiol levels than patients with active
disease, and produced some values that were higher than
normal wellness values.
Serum thiols are primary antioxidants, and serve as a measure
of human health status. The test provides a surrogate estimate
of DNA repair enzyme activity, which has been shown to correlate
with lifespan and aging.
Dr. Christopher Kent, one of the authors explained, “Going
through life, we experience physical, chemical, and emotional
stress. These stresses affect the function of the nervous
system. We hypothesized that these disturbances in nerve
function could affect oxidative stress and DNA repair on
a cellular level.”
“Oxidative stress, metabolically generating free radicals,
is now a broadly accepted theory of how we age and develop
disease,” Kent continued. “Oxidative stress results in DNA
damage, and inhibits DNA repair. DNA repair is the mechanism
which fixes the damage caused by environmental impact.”
Chiropractors apply spinal adjustments to correct disturbances
of nerve function. “Chiropractic care appears to improve
the ability of the body to adapt to stress,” continued Kent.
“Further research is needed to gain additional insights
that will ultimately lead to improved clinical outcomes,”
he said.
The study was a collaborative involving Camgen, Inc. of
Victoria, B.C. Canada; Chiropractic Leadership Alliance
in Mahwah, NJ; Biomedical Diagnostic Research, LLC in Chesterland,
Ohio; and Department of Cell and Molecular Biology of Tumor
Immunology, University of Lund, Sweden.
JVSR is a peer-reviewed scientific journal devoted to subluxation-based
chiropractic research affiliated with the World Chiropractic
Alliance (WCA), an international organization representing
doctors of chiropractic. WCA promotes the traditional, drug-free
and non-invasive form of chiropractic as a means of correcting
vertebral subluxations that cause nerve interference.
World
Chiropractic Alliance (WCA)
Chandler, AZ 85224
United States
Phone 800-347-1011
http://www.worldchiropracticalliance.org
April
13, 2005
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