Broccoli and red chili peppers
may help fight cancer by slowing the growth of cancerous
tumor cells, U.S. researchers reported.
They may be especially
helpful in hard-to-treat cancers such as pancreatic and
ovarian cancer, the team at the University of Pittsburgh
said.
"In our studies, we decided
to look at two particular cancers -- ovarian and pancreatic
-- with low survival rates, to ascertain the contribution
of diet and nutrition to the development of these cancers,"
said Sanjay Srivastava, who led the study.
"We discovered that red
chili pepper and broccoli appear to be effective inhibitors
of the cancer process."
Speaking to a meeting of
the American Association for Cancer Research in Anaheim,
California, Srivastava said he and colleagues tested capsaicin,
which makes peppers hot, against pancreatic cancer cells
in a lab dish.
The compound caused the
cancer cells to self-destruct in a process called apoptosis,
while not affecting normal pancreatic cells.
"Our results demonstrate
that capsaicin is a potent anticancer agent, induces apoptosis
in cancer cells and produces no significant damage to
normal pancreatic cells, indicating its potential use
as a novel chemotherapeutic agent for pancreatic cancer,"
Srivastava said.
His team also examined
phenethyl isothiocyanate (PEITC), a constituent of cruciferous
vegetables such as broccoli, on ovarian cancer cells.
PEITC interfered with a
protein called epidermal growth factor receptor, which
is involved in the growth of ovarian and other cancerous
tumors.
The studies may help explain
why people who eat large amounts of fruits and vegetables
have a lower risk of cancer, Srivastava said.