Children may be at increased risk
of diabetes if their grandmothers had a poor diet
while pregnant and breastfeeding, animal studies suggest.
Scientists found insulin resistance
- which can lead to diabetes - may be programmed across
two generations.
They showed grandchildren of rats
denied proper nutrition during pregnancy were at greater
risk of obesity and insulin resistance.
The University of Texas study is
published by the Journal of Physiology.
But UK diabetes experts said much
more research was needed before the link could be
confirmed.
Previous research has suggested that a child may be
at increased risk of diabetes if their mother's diet
was poor during pregnancy and breastfeeding.
But the US team, who collaborated
with researchers from Mexico, believe their work is
the first to show the effect may be passed down the
next generation too.
Researcher Professor Peter Nathanielsz
said: "These new findings stretch the unwanted consequences
of poor nutrition across generations.
"It offers us important clues about
the origins of insulin resistance and type 2 diabetes."
The study showed that granddaughters
were particularly vulnerable if their grandmothers'
diet was not up to scratch during pregnancy. The effect
seemed to be less pronounced for grandsons.
However, boys seemed to be more affected
if their mothers failed to get sufficient nutrients
when being breastfed.
Dr Nathanielsz said the results underlined
just how important it was that women eat well during
pregnancy, and in the first few moths after giving
birth.
However, he said further research
was needed to determine the precise mechanisms at
play.
The global incidence of type 2 diabetes
is projected to double to 300 million by 2025.
The disease is responsible for early
death, painful and debilitating complications such
as limb amputation and blindness.
Natasha Ede, Care Advisor at Diabetes
UK, said, "This is interesting research. We already
know that it is important for women to eat a healthy,
balanced diet before conception and during and after
pregnancy.
"However much more research needs
to be done before we draw any firm conclusions about
the direct effects of a poor diet during pregnancy
and the links to diabetes."