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Obesity, Smoking Speed Aging Process
Researchers are providing one more
reason to drop excess weight and quit smoking: a
new study finds that both accelerate human aging.
The new study included more than 1,100 British
women between 18 and 76 years of age. The women
filled out a questionnaire on their smoking history
and provided blood samples, which were also tested
for concentrations of a body fat regulator called
leptin and for telomere length.
Telomeres cap the ends of chromosomes in cells
and protect them from damage. However, each time
a cell divides -- and as people age -- these caps
get shorter, so decreases in telomere length have
long been associated with the aging process.
Reporting June 14 in the early online edition of
The Lancet, the British researchers found
that telomeres of obese women and smokers were much
shorter than those of lean women and those who'd
never smoked. In contrast, lean women had much longer
telomeres than moderately overweight women who,
in turn, had longer telomeres than obese women.
Each pack-year (the number of cigarettes smoked
per day times the number of years of smoking) smoked
was equivalent to an 18 percent telomere shortening,
in addition to normal telomere shrinkage, the study
found.
Overall, obese women aged an additional 8.8 years
-- based on telomere length -- compared to lean
women, the researchers reported. A current or previous
history of smoking entailed an average 4.6 year
increase in aging compared to never-smokers, while
those with long-term smoking habits -- a pack-a-day
for 40 years -- added an additional 7.4 years of
aging to their life compared to those who stayed
away from cigarettes completely, the study found.
"Our results emphasize the potential wide-ranging
effects of the two most important preventable exposures
in developed countries -- cigarettes and obesity,"
researcher Tim Spector of St. Thomas' Hospital,
U.K., said in a prepared statement.