High-dose folic acid pills providing as much of
the nutrient as 2.5 pounds of strawberries might
help slow the cognitive decline of aging. So says a Dutch
study that's the first to show a vitamin could really improve
memory.
The research, unveiled Monday at a meeting of Alzheimer's
researchers, adds to mounting evidence that a diet higher
in folate is important for a variety of health effects.
It's already proven to reduce birth defects, and research
suggests it helps ward off heart disease and strokes, too.
The new study doesn't show folic acid could prevent Alzheimer's
the people who tested the vitamin didn't have symptoms
of that disease.
But as people age, some decline in memory and other brain
functions is inevitable. Taking 800 micrograms of folic
acid a day slowed that brain drain, reported lead researcher
Jane Durga of Wageningen University in the Netherlands.
In the study, 818 cognitively healthy people ages 50 to
75 swallowed either folic acid or a dummy pill for three
years.
On memory tests, the supplement users had scores comparable
to people 5.5 years younger, Durga said. On tests of cognitive
speed, the folic acid helped users perform as well as people
1.9 years younger.
That's significant brain protection, with a supplement
that's already well-known to be safe, said Johns Hopkins
University neuroscientist Marilyn Albert, who chairs the
Alzheimer's Association's science advisory council.
"I think I would take folic acid, assuming my doctor said
it was OK," Albert said. "We know
Alzheimer's disease, the pathology, begins many,
many years before the symptoms. We ought to be thinking
about the health of our brain the same way we think about
the health of our heart."
Indeed, there's enough research now suggesting that there
are ways to gird the brain against age-related memory loss
and Alzheimer's that the association has begun offering
classes to teach people the techniques.
Topping the list:
_Exercise your brain. Using it in unusual ways increases
blood flow and helps the brain wire new connections. That's
important to build up what's called cognitive reserve, an
ability to adapt to or withstand the damage of Alzheimer's
a little longer.
In youth, that means good education. Later in life, do
puzzles, learn to play chess, take classes.
_Stay socially stimulated. Declining social interaction
with age predicts declining cognitive function.
_Exercise your body. Bad memory is linked to heart disease
and diabetes because clogged arteries slow blood flow in
the brain.
Experts recommend going for the triple-whammy of something
mentally, physically and socially stimulating all at once:
Coach your child's ball team. Take a dance class. Strategize
a round of golf.
Diet's also important. While Alzheimer's researchers have
long recommended a heart-healthy diet as good for the brain,
Monday's folic acid study is the first to test the advice
directly.
Previous studies have shown that people with low folate
levels in their blood are more at risk for both heart disease
and diminished cognitive function.
Durga said it's not clear how folic acid might work to
protect the brain. Some studies suggest folate lowers inflammation;
others suggest it may play a role in expression of dementia-related
genes.
Folate is found in such foods as oranges and strawberries,
dark-green leafy vegetables and beans. In the United States,
it also is added to cereal and flour products. The recommended
daily dose here is 400 micrograms; doctors advise women
of childbearing age to take a supplement to ensure they
get that much.