Asthmatics prone to exercise-triggered attacks may want
to cut back on salt in their diets, according to a new study.
The Indiana University research is the first to show that
changing salt intake for just two weeks can alter airway
inflammation, and the flow of oxygen into the bloodstream.
The study included 24 people with asthma and exercise-induced
asthma. Some of the study volunteers were put on a low-salt
diet of 1,446 milligrams of sodium per day for two weeks.
Others were put on a high-salt diet of 9,873 milligrams
of sodium per day, an amount that's typical for many American
adults.
At the end of two weeks, the volunteers on the high-salt
diet showed a dramatic decline in lung function after physical
activity. Their forced expiratory volume in one second (FEV1)
-- a standard measure of lung function -- taken 20 minutes
after exercise dropped by 27.4 percent over the two weeks,
compared with a 7.9 percent decline for those on the low-salt
diet.
A decline of 10 percent or more in post-exercise FEV1 is
considered abnormal.
"These findings show that modifying your diet has the potential
to modify a disease state," study author and exercise physiologist
Timothy Mickleborough said in a prepared statement.
High-salt diets have a number of physiological effects,
including increased blood pressure and blood volume that
can cause pulmonary swelling that, in turn, results in airway
obstruction, Mickleborough explained.
The study volunteers on the high-salt diet also had higher
levels of airway cells in their sputum. Airway cells have
been linked to the development of asthma and EIA. The people
on the high-salt diet also had more pro-inflammatory mediators,
which can cause airway constriction.
The findings appear in the June issue of Medicine &
Science in Sports & Exercise.