Scientists believe that knowing exactly which type of dirt
provides the best 'education' for the immune system, could be
key to providing new treatments for diseases such as asthma.
Speaking at the launch of the BA Festival of Science today,
Professor Peter Openshaw, explains that a lack of exposure to
dirt and common viral infections among children could be behind
the rise in the levels of asthma.
Professor Openshaw, from Imperial College London, and based
at St Mary's Hospital, says: "Although we have seen a dramatic
decline in many previously common childhood infections over
the past 100 years, we have also seen a considerable rise in
the prevalence of diseases such as asthma. The increase in asthma
cannot be blamed purely on changes in genetic risk, so must
be down to environmental factors."
Scientists have called this the 'hygiene' hypothesis, with
a lack of exposure to viruses and other environmental factors
meaning children are not able to build up resistance, and can
become more susceptible to disease later in life. They also
believe having many older siblings, attending day care at an
early age, or growing up on a farm can help in promoting resistance
to disease.
Studies have shown that most common colds can help protect
against wheezing in later childhood, and other childhood infections
such as chickenpox also provide a level of protection.
Professor Openshaw adds: "The challenge now is to find ways
of reproducing the protective effects of early childhood infections,
while reducing the burden of actually getting these infectious
diseases. Knowing exactly which 'dirt' provides the best education
for the immune system, and how to mimic its affects in a cleaner
environment, could be the key to reducing the rise in the prevalence
of asthma and related diseases."
Professor Openshaw is a respiratory medicine researcher, looking
at immunological responses to diseases such as asthma, the common
cold and other lung diseases.