Maybe it's germs that are
making you fat.
Researchers found a strong
connection between obesity
and the levels of certain
types of bacteria in the gut.
That could mean that someday
there will be novel new ways
of treating obesity that go
beyond the standard advice
of diet and exercise.
According to two studies
being published in Thursday's
issue of the journal Nature,
both obese mice and people
had more of one type of bacteria
and less of another kind.
A "microbial component" appears
to contribute to obesity,
said study lead author Jeffrey
Gordon, director of Washington
University's Center for Genome
Sciences.
Obese humans and mice had
a lower percentage of a family
of bacteria called Bacteroidetes
and more of a type of bacteria
called Firmicutes, Gordon
and his colleagues found.
The researchers aren't sure
if more Firmicutes makes you
fat or if people who are obese
grow more of that type of
bacteria.
But growing evidence of this
link gives scientists a potentially
new and still distant way
of fighting obesity: Change
the bacteria in the intestines
and stomach. It also may lead
to a way of fighting malnutrition
in the developing world.
"We are getting more and
more evidence to show that
obesity isn't what we thought
it used to be," said Nikhil
Dhurandhar, a professor of
infection and obesity at Louisiana
State University's Pennington
Biomedical Research Center.
"It isn't just (that) you're
eating too much and you're
lazy."
Dhurandhar wasn't part of
the research, but said it
may change the way obesity
is treated eventually.
He said the field of "infectobesity"
looks at obesity with multiple
causes, including viruses
and microbes. In another decade
or so, the different causes
of obesity could have different
treatments. The current regimen
of diet and exercise "is like
treating all fevers with one
aspirin," Dhurandhar said.
In one of the two studies
in Nature, Gordon and colleagues
looked at what happened in
mice with changes in bacteria
level. When lean mice with
no germs in their guts had
larger ratios of Firmicutes
transplanted, they got "twice
as fat" and took in more calories
from the same amount of food
than mice with the more normal
bacteria ratio, said Washington
University microbiology instructor
Ruth Ley, a study co-author.
It was as if one group got
far more calories from the
same bowl of Cheerios than
the other, Gordon said.
In a study of dozen dieting
people, the results also were
dramatic.
Before dieting, about 3 percent
of the gut bacteria in the
obese participants was Bacteroidetes.
But after dieting, the now
normal-sized people had much
higher levels of Bacteroidetes
close to 15 percent,
Gordon said.
"I think that gut bacteria
affects body weight," said
Virginia Commonwealth University
pathology professor Richard
Atkinson, who wasn't part
of the research team and is
president of Obetech Obesity
Research Center in Richmond.
"I don't think there's any
doubt about that and they
showed that."
The growing field of research
puts more importance in the
trillions of microbes that
live in our guts and elsewhere,
crediting it with everything
from generations of people
getting taller to increases
in diabetes and asthma.
People are born germ-free,
but within days they have
a gut blooming with microbes.
The microbes come from first
foods either breast
milk or formula the
exterior environment, and
the way the babies are born,
said Stanford University medicine
and microbiology professor
David Relman, who was not
part of the study.
For decades, doctors have
treated bacteria in a "warlike"
manner, yet recent research
shows that "most encounters
we have with microbes are
very beneficial," Gordon said.
"Much of who we are and
what we can do and can't do
as human beings is directly
related to microbial inhabitants,"
Relman said.