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Study Suggests More
Frequent Breast Exams Needed
Women who carry a genetic mutation
linked to a higher risk of breast cancer often are at advanced
stages of the disease months before they go to the doctor for
an annual screening, according to a new U.S. study.
The finding by researchers at Columbia-Presbyterian
Medical Center in New York suggests more frequent mammograms and
ultrasound screening may be needed for the small percentage of
women who carry the BRCA1 and BRCA2 genes.
These genetic markers, which are
more common among Ashkenazi Jews, account for between 5 percent
and 10 percent of the estimated 180,000 breast cancer cases diagnosed
in the United States each year.
Carriers have a 60 percent to 85
percent lifetime risk of contracting the disease, which kills
about 44,000 women in the United States each year.
In their study of 13 women aged
32 to 59 with these genes, researchers at Columbia-Presbyterian
found six had developed breast cancers detected in between their
annual mammograms.
The average time that had elapsed
since their last annual screening was about five months, and four
of the six had already developed relatively advanced cancers that
had spread to their lymph nodes.
"We feel that (every) 12 months
definitely is not adequate screening for women with these genetic
mutations," said Dr. Ian Komenaka, a breast surgeon and lead author
of the study, published on Monday in the online edition of the
American Cancer Society journal Cancer.
"It looks like it needs to be every
six months if not every four months," Komenaka said.
Mammography, a special type of
X-ray imaging used to create detailed images of a breast, is the
primary method of screening for breast cancer in the United States.
In 1997, the National Cancer Institute recommended women 40 years
and older have this exam every one to two years.
While many researchers credit regularly
scheduled mammograms for helping reduce breast cancer mortality
in women over the age of 50, the role and frequency of the practice
remains a controversial subject.
A study by Swedish researchers
four years ago suggested the average woman did not gain any survival
benefit from having regular mammograms.
Reference
Source 89
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