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Lifetime Activity Cuts Breast Cancer Risk

NEW YORK (Reuters Health) - Women who have remained active throughout their lives may have a lower breast cancer risk than their habitually sedentary counterparts, study findings suggest.

The investigators found that postmenopausal women who reported the highest levels of activity were 30% less likely to be diagnosed with breast cancer than women with the lowest activity levels were. Household and occupational activity--rather than recreational activities such as sports or exercise class--appeared to provide the most protection, the researchers report.

Physical activity was found to provide the greatest benefits for active postmenopausal women who also did not smoke, drink alcohol and had never given birth, the report indicates.

``This study provides evidence that lifetime total activity reduces risk of postmenopausal breast cancer,'' according to researchers led by Dr. C. M. Friedenreich from the Alberta Cancer Board in Canada.

The team compared more than 1,200 breast cancer patients with a similar number of women without breast cancer. Women were interviewed about their menstrual and reproductive histories, use of hormones, family breast cancer history, physical activity patterns, diets and other health factors.

Their study, published in the August 15th issue of the American Journal of Epidemiology, found no associations between physical activity and risk of breast cancer for premenopausal women.

The findings add to a growing body of evidence linking physical activity to a reduced risk of breast cancer. Although sports and recreational activity did not have a strong effect in this study, a number of previous studies have linked recreational exercise with a lower breast cancer risk.

However, exactly how activity may cut a woman's risk is not yet clear. Researchers have speculated that factors such as reduced body fat or enhanced immunity may explain the connection.

``Numerous questions remain regarding the...role of physical activity and breast cancer that need to be addressed in studies that examine more specifically the underlying hypothesized biologic mechanism,'' the study authors conclude.

SOURCE: American Journal of Epidemiology 2001;154:336-347.

Reference Source 89

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