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Better Diet May Help
Prevent Breast Cancer

NEW YORK (Reuters Health) - A diet rich in fruits and vegetables may reduce a woman's risk of developing breast cancer, according to researchers from New York University and the International Agency for Research on Cancer in Lyon, France.

Only a handful of previous studies have examined the link between vegetable intake and breast cancer, and their results have been conflicting, according to Dr. Paolo Toniolo, from New York University, and associates.

In a new study, the researchers compared the blood levels of carotenoids in 270 women who developed breast cancer up to 11 years after the blood samples were taken with the levels seen in 270 similar women who remained cancer-free. Carotenoids are chemicals derived from vegetables and fruits.

On average, women who developed breast cancer had significantly lower levels of a variety of carotenoids before they were diagnosed with cancer than did women without breast cancer--11% to 21% lower, in fact, according to the report in the June 15th issue of the American Journal of Epidemiology.

Overall, those women with the lowest blood levels of carotenoids were more than twice as likely to develop breast cancer as those women with higher levels.

This was particularly true for beta-carotene, which is found in carrots and dark green leafy vegetables, and alpha-carotene, found in carrots and tomato-based vegetable juices.

The study could not determine if diet was indeed responsible for a reduction in breast cancer risk. It is possible that women with healthier diets had other lifestyle factors that affected cancer risk.

However, the authors do believe that diet may help reduce breast cancer risk.

``Our hypothesis is that blood levels of carotenoids are an indicator of habitual intake of vegetables and fruits, and that the protection from breast cancer that we observe is the result of a diet rich in these foods,'' Toniolo told Reuters Health. ``The fact that we observe a protection not only for beta-carotene, but also for other compounds, and for total carotenoids, seem to offer some support to our theory.''

Toniolo's advice? ``Eat as much fruits and vegetables as possible.''

SOURCE: American Journal of Epidemiology 2001;153:1142-1147.

Reference Source 89

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