Blood
Test Helps Catch
Congestive Heart Failure
Excerpt
By Amy Norton,
Reuter's Health
NEW YORK (Reuters Health) - A simple blood test
can help spot emergency department patients with congestive heart
failure, potentially getting them the necessary treatment quicker,
according to researchers.
Their international study of nearly 1,600 emergency patients with
shortness of breath found that the 15-minute test--which measures
a hormone called B-type natriuretic peptide (BNP)--was the single
most accurate predictor of heart failure in the set of criteria
the researchers used.
Congestive heart failure is a chronic condition
in which the heart loses its ability to pump efficiently, often
due to an underlying cardiac problem such as coronary artery disease.
Shortness of breath is a prime symptom, but when patients arrive
at the emergency department with breathing problems, it can be
difficult to distinguish whether it's due to heart failure or
other causes.
According to the authors of the new study, the
BNP test--used along with other patient information--"should lead
to more accurate initial diagnoses of congestive heart failure."
Dr. Alan S. Maisel, of the University of California,
San Diego, and his colleagues report the findings in the July
18th issue of The New England Journal of Medicine.
The study was partially funded by Biosite Inc.,
whose Triage BNP test was approved by the US Food and Drug Administration
in 2000 to aid in the diagnosis of congestive heart failure.
BNP is a hormone secreted from the heart's ventricles
in response to increased pressure and volume in the organ. The
hormone helps relieve this stress by promoting the release of
fluid and sodium from the body, and BNP levels have been found
to be elevated in the blood of people with heart failure.
In the new study, Maisel's team found that out
of all patients, 47% were ultimately diagnosed with congestive
heart failure. And the BNP test was the single most accurate predictor
of heart failure, in a set of criteria that included patients'
medical history and chest x-rays.
"The use of this test is increasing, and studies
such as this will encourage greater utilization," Dr. Kenneth
L. Baughman of Johns Hopkins Hospital in Baltimore, Maryland,
told Reuters Health. Baughman wrote a commentary published with
the report.
He noted that along with confirming heart failure
as the cause of patients' shortness of breath, the BNP test can
help judge the severity of heart failure, estimate patients' prognosis,
and judge the effectiveness of heart failure therapy.
However, Baughman pointed out, the test will
not replace echocardiography, which uses ultrasound waves to produce
images of the heart in action.
SOURCE: The New England Journal of Medicine
2002;347:161-167.
Reference
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