US
Study Ties Gene to
Memory Loss in Healthy Adults
Excerpt
By Christopher
Doering,
Reuters Health
WASHINGTON (Reuters) - A gene already linked to Alzheimer's and
heart disease can also cause everyday memory loss in healthy people
as they age, US researchers said on Tuesday.
A study of people 55 and older found that the nerve cell activity
in the front of the brain declined three times faster among those
who had a gene variation called APOE4 when compared to those who
did not have the gene.
The findings, presented at the American Association for Geriatric
Psychiatry in Orlando, could allow researchers to understand why
some people age faster than others, and design drugs to slow the
process.
"This gene appears to be very closely related to how a nerve
cell can repair itself or survive after different types of insults,"
Dr. P. Murali Doraiswamy of Duke University in North Carolina
said in a telephone interview. "If you carry this gene, your nerve
cells appear less capable of repairing themselves."
Doraiswamy and his colleagues compared the levels of frontal
lobe brain activity in 165 healthy people between the ages of
55 and 85. The frontal lobe is important to memory.
The subjects were then separated depending on whether or not
they carried the APOE4 gene.
Brain activity declined 28% in people who had active copies
of APOE4 gene compared to 9% in people who did not have the gene,
the study found.
APOE4 is found in 25% of the population and has been linked
to higher levels of Alzheimer's, cardiovascular disease and memory
loss.
Doraiswamy said even though the discovery of APOE4 could lead
to the development of drugs to slow the aging process, more experiments
must be done to find what this gene does to cause the brain to
age faster.
"But we have a ways to go and clearly this finding is not going
to have any clinical applications right away in people," he added.
A separate study published by Duke researchers has identified
the average age at which people begin to develop memory loss.
Alzheimer's affects people beginning at 72.8 years old and Parkinson's
at 60.1, researchers found.
The study, published in the American Journal of Human Genetics,
studied 449 families with a history of Alzheimer's and 174 with
multiple cases of Parkinson's disease.
Reference
Source 89
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