Smoking Speeds Up
Memory Loss in Middle Age
Excerpt By Alison McCook, Reuters Health

Cigarette smokers who continue the habit through middle age may see their memory suffer as a result, according to new study findings released Wednesday.

UK researchers found that, from their 40s to their 50s, smokers showed a faster decline in their scores on tests of word memory, relative to non-smokers.

Furthermore, people who smoked in their 40s did worse on tests that measure how fast they could pick out certain letters from a page than non-smokers of the same age, the authors write in the American Journal of Public Health.

The relationship between smoking and memory loss appeared strongest in people who smoked more than 20 cigarettes each day, and persisted even when the authors controlled for the influence of socioeconomic status, gender and a range of medical conditions.

Just why smoking may speed up age-related memory loss is not yet clear, study author Dr. Marcus Richards of University College London told Reuters Health.

He said that he and his colleagues suspected that smoking may accelerate memory loss by increasing the risk of high blood pressure, which can damage the brain. However, the relationship between smoking and brain functioning may be slightly more complicated, Richards said.

"Our results for memory still held up after taking blood pressure into account, but smoking could have been causing changes in the brain's blood supply that we were not able to measure," he said.

Alternatively, chemicals in cigarette smoke could also damage the brain directly, Richards added.

Whatever the reasons for why smoking accelerates memory loss, the message from these results should be clear, Richards said.

"This is yet another reason to quit smoking," he said. "If you can't, then cut down as much as you can."

During the study, Richards and his team reviewed information collected from 5,362 people born in 1946. Study participants were contacted 21 times by the time they turned 53.

Researchers measured people's mental functioning via a series of tests. In one test, which looked at verbal memory, the investigators showed people 15 words for two seconds each, then asked them to write down as many as they could remember.

During tests of speed and concentration, people had to look for and cross out as many Ps and Ws they could find in a page of other letters within one minute.

Although smokers in their 40s performed just as well as non-smokers in the verbal memory tests, puffers' performance deteriorated much faster from their 40s to their 50s.

And people who said they smoked while in their 40s scored worse during speed tests conducted in their 40s than non-smokers.

But the findings also suggest that quitting may help, for the researchers discovered that people who stopped smoking before age 53, and especially those who stopped before age 43, tended to exhibit a slower decline in memory.

"Our results suggest that quitting may slow down the negative impact of smoking on cognitive function," Richards said.

SOURCE: American Journal of Public Health 2003;93.

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