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  APRIL 29, 2019 by KAREN FOSTER
Breastfeeding Boosts Metabolites Important For Brain Growth


Preemies who primarily consume breast milk have significantly higher levels of metabolites important for brain growth and development, according to sophisticated imaging conducted by an interdisciplinary research team at Children's National.


Breast milk is always better than formula because it provides critical nutrients and a diverse array of antioxidant protection as well.

Earlier studies have shown that breast milk lowers the incidence of diarrhea, influenza and respiratory infections during infancy, while protecting against the later development of allergies, type 1 diabetes, multiple sclerosis and other illnesses.

Some studies have even suggest that children up to the age of one that are fed beverages other than breast milk are at risk of becoming malnourished.


The excitement around the impact of breast milk on microorganisms in the gut, called the microbiota, has largely focused on bacteria, with little known about fungi. But fungi could be important to the development of allergies or disease later in life.

Babies fed a dairy-based formula grow up to have higher blood pressure than babies who are breast-fed.

"Our previous research established that vulnerable preterm infants who are fed breast milk early in life have improved brain growth and neurodevelopmental outcomes. It was unclear what makes breastfeeding so beneficial for newborns' developing brains," says Catherine Limperopoulos, Ph.D., director of MRI Research of the Developing Brain at Children's National. "Proton magnetic resonance spectroscopy, a non-invasive imaging technique that describes the chemical composition of specific brain structures, enables us to measure metabolites essential for growth and answer that lingering question."

According to the Centers for Disease Control and Prevention, about 1 in 10 U.S. infants is born preterm. The Children's research team presented their findings during the Pediatric Academic Societies 2019 Annual Meeting.

The research-clinicians enrolled babies who were very low birthweight (less than 1,500 grams) and 32 weeks gestational age or younger at birth when they were admitted to Children's neonatal intensive care unit in the first week of life. The team gathered data from the right frontal white matter and the cerebellum -- a brain region that enables people to maintain balance and proper muscle coordination and that supports high-order cognitive functions.

Each chemical has its own a unique spectral fingerprint. The team generated light signatures for key metabolites and calculated the quantity of each metabolite. Of note:

  • Cerebral white matter spectra showed significantly greater levels of inositol (a molecule similar to glucose) for babies fed breast milk, compared with babies fed formula.
  • Cerebellar spectra had significantly greater creatine levels for breastfed babies compared with infants fed formula.
  • And the percentage of days infants were fed breast milk was associated with significantly greater levels of both creatine and choline, a water soluble nutrient.


"Key metabolite levels ramp up during the times babies' brains experience exponential growth," says Katherine M. Ottolini, the study's lead author. "Creatine facilitates recycling of ATP, the cell's energy currency. Seeing greater quantities of this metabolite denotes more rapid changes and higher cellular maturation. Choline is a marker of cell membrane turnover; when new cells are generated, we see choline levels rise."

Already, Children's National leverages an array of imaging options that describe normal brain growth, which makes it easier to spot when fetal or neonatal brain development goes awry, enabling earlier intervention and more effective treatment. "Proton magnetic resonance spectroscopy may serve as an important additional tool to advance our understanding of how breastfeeding boosts neurodevelopment for preterm infants," Limperopoulos adds.


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